منابع مشابه
Stuck in the divide
n the nervous system, guidance molecules called semaphorins bind to receptors called plexins to induce motility and regulate axonal pathfinding. Now, Swiercz et al. (page 869) show that plexin-B1, after binding its ligand semaphorin 4D (Sema4D), forms a heterodimer with the tyrosine kinase ErbB2. This raises the intriguing possibility that the semaphorins and the EGF-like ligands of ErbB recept...
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چکیده ندارد.
15 صفحه اولDon't get stuck in the pore.
Eukaryotic cells critically rely on a constant and intensive exchange of macromolecules between the cytoplasm and nucleoplasm across the barrier of the nuclear envelope. Nuclear pore complexes (NPCs) function as gates to mediate this transport, but why they grant the selective passage of transport receptor–cargo complexes and at the same time exclude most other cellular macromolecules is incomp...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2015
ISSN: 1933-7213,1878-7479
DOI: 10.1007/s13311-014-0333-7